Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Experience the authentic Southern Kentucky lifestyle in Wayne County, with Monticello serving as its county seat. This South Central Kentucky county, home to over 20,000 people, boasts scenic beauty and abundant natural resources, making it an attractive destination for land buyers seeking affordability and a connection to nature, especially near Lake Cumberland.