Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Warren County is the economic hub of South Central Kentucky, anchored by Bowling Green. Home to Western Kentucky University, a growing industrial base, and affordable rural acreage just minutes from city amenities.