Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Metcalfe County is a small rural county centered on Edmonton in South Central Kentucky. Among the most affordable land markets in the state, with rolling hills, creek bottoms, and a strong agricultural tradition.