Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Find serenity and affordability in Menifee County, Eastern Kentucky, with Frenchburg as its county seat. This sparsely populated county of around 6,300 residents is characterized by its natural beauty, offering secluded land perfect for off-grid living, homesteading, or a peaceful recreational escape.