Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Experience the convenience of city amenities with rural tranquility in McCracken County, Western Kentucky, led by Paducah. As the most populous county on this list with over 66,000 residents, it offers diverse land options, from development tracts to spacious residential parcels near major transportation hubs.