Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Letcher County, in Eastern Kentucky and with Whitesburg as its seat, supports a population of approximately 21,553 and is deeply rooted in Appalachian culture, offering land with stunning mountain vistas and the potential for establishing a homestead amidst breathtaking natural scenery.