Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Eastern Kentucky's Lee County, with Beattyville as its seat and a population of roughly 6,474, features dramatic landscapes shaped by the Kentucky River and its tributaries, offering secluded parcels for those seeking a private, nature-centric homestead experience.