Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Laurel County in Eastern Kentucky is centered on London, a growing regional hub. Access to I-75, Daniel Boone National Forest, and Levi Jackson State Park combine with affordable acreage and low regulation.