Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Discover the Appalachian allure of Eastern Kentucky's Knott County, with its county seat in Hindman. This community of around 14,884 residents is perfect for land buyers and homesteaders seeking secluded natural beauty, affordable acreage, and a chance to immerse themselves in the rich culture of the mountains.