Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Nestled in the heart of the Bluegrass region, Jessamine County offers prime land opportunities with its county seat in Nicholasville. Boasting a population of over 55,591, this rapidly growing area provides convenient access to Lexington while retaining its agricultural charm, making it ideal for those seeking scenic land for development or a peaceful Bluegrass lifestyle.